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Product Advantage:

1. MELDRUMS ACID is our advantage products which produced by ourselves in GMP workshop and free sample can be provided.

2.Stable supply with high quality.

3.Good quality and stability is excellent within one year chemical property will not have any change.

4.GMP factory with reliable quality system and large-scale production.

5.With complete set of docments.

 

BASIC INFO

Brief Introduction
Name	Meldrum's Acid
Synonyms	2,2-Dimethyl-1,3-Dioxane-4,6-Dione
	Isopropylidene Malonate
	Malonic Acid Cyclic Isopropylidene Ester
	Cyclic Isopropylidene Malonate
CAS	2033-24-1
EINECS	217-992-8
Molecular Formula	C6H8O4
Molecular weight	144.13
Pureness	≥99%
Production Capacity	200 tons/month

Properties

Properties
Density	1.1311 (rough estimate)
Melting Point	92-96°C(lit.)
Boling Point	182.71°C (rough estimate)
Flash Point	150.1°C
Water Solubility	2.5 g/100 mL (20 ºC)
Vapor Presure	0.044-133Pa at 25ºC
Appearance	White crystalline powder
Merck	145817
BRN	117310
pKa	5.1(at 25ºC)
Storage Condition	2-8°C
Refractive Index	1.4434 (estimate)
MDL	MFCD00006638
InChI	InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3
InChIKey	GXHFUVWIGNLZSC-UHFFFAOYSA-N

 

Product Description
Due to its unique structure and the vast array of substituents that can be attached to its core, Meldrum's acid is a molecule with exceptional chemical properties. In water, it has a remarkably low pKa value of about 4.9. Its C5 position is readily involved in electrophilic substitution reactions whereas the C4 and C6 positions are easily attacked by nucleophiles. At elevated temperatures Meldrum's acid undergoes distinctive decomposition pathways, which can be used in cycloaddition and acylation reactions. 

Solubility
Meldrum's acid or 2,2-dimethyl-1,3-dioxane-4,6-dione is an organic compound with formula . Its molecule has a heterocyclic core with four carbon and two oxygen atoms; the formula can also be written as [−O− (C (CH3)2)−O− (C=O)− (CH2)− (C=O)−]  . It is a crystalline colorless solid, sparingly soluble in water. It decomposes on heating with release of carbon dioxide and acetone.

Stability

1. It will not decompose if used and stored according to specifications. No known hazard reactions. Avoid oxides, moisture/moisture.
2. It's very stable and can be stored for a long time at room temperature.

Storage Attentions
Keep the storage device sealed and stored in a cool, dry place. Ensure that the workshop is well ventilated or vented.

 

Application

1. It's used as a pharmaceutical intermediate. The ring (sub) isopropyl malonate can be used as an intermediate in pharmaceutical synthesis, and it can be used to prepare the compound 3-oxo-4-phenylvalerate Ethyl, further preparation of 3, 4-disubstituted-6-phenylethylpyridinone HIV-1 reverse transcriptase inhibitors.

2. It's used in organic synthesis.The protective reagent is obtained by aldol condensation and reduction with triethylamine formaldehyde. the benzyl substituted michele acid is hydrolyzed, lost CO2 and chlorosulfonic acid for Friedel-Crafts cyclization to produce 2, 3-dihydro-2-indanone. Accelerate the Noven Gall concentration reaction between aldehyde and Michaelis acid in ionic liquid (Knoevenagel condensations).

 

COMPANY PROFILE

Taizhou Zhenyu Biotech Co.,LTD , Sister Company of Ningbo Zhenlei Chemical co.,ltd ,is a rapid growing company , We are one of TOP supplier and manufactuer of Human APIs, Veterinary API, Pet Animal API, Pesticide, and intermediates for dyestuff, LCD,OLED, Surfactant ect.
 
OUr R&D team focuses on the product group positioning of stomach medicine, diabetes medicine, anticancer medicine and other fields, focusing on pesticide, dye and other fields, focusing on the green new process development of strategic intermediates of important varieties. In terms of new drug R & D, technological process optimization and upgrading, product quality control and other aspects, it has achieved breakthroughs in process technology and quality control technology and ensured the enterprise R & D capability and quality management level of original new drugs. Gradually achieve the goal of creating an international pharmaceutical enterprise with outstanding value creation ability, and make China Pharmaceutical recognized by the world!

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